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Topical application of oxymetazoline nasal spray may be recommended by your dermatologist as a cost-effective treatment for persistent facial redness of rosacea or post-acne redness. While it is recommended off-label for these uses, it can be pretty effective and well-tolerated. Application site dermatitis is the most frequently encountered adverse effect. Tachyphlaxis and rebound redness remain a theoretical concern, though there are no reported cases. I don’t recommend self-treating facial red