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1:48
YouTube
Anant`s Pharmacology
Thiazolidinediones (TZDs) – Mechanism of Action & Side Effects | Pioglitazone | Rosiglitazone Part 1
TZDs activate a nuclear receptor called PPAR-γ (Peroxisome Proliferator-Activated Receptor-gamma) found mainly in adipose tissue, liver, and skeletal muscle. Activation leads to: Increased GLUT-4 expression → ↑ Glucose uptake Increased Adiponectin → ↑ Insulin sensitivity Reduced Insulin resistance Improved fat and glucose metabolism ...
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