How to Calculate Transferrin Saturation for Iron Deficiency

High ferritin isn’t just “extra iron.” It can mean a few very different things — and the next steps depend on why it’s elevated. If my ferritin came back high, here’s exactly what I’d do: 1️⃣ I’d confirm it — and look at the full iron panel. Ferritin alone isn’t the full picture. I’d review: • serum iron • TIBC / transferrin • transferrin saturation • hemoglobin and hematocrit • trends over time High ferritin with high transferrin saturation means something different than high ferritin with norm

Most cases of hereditary hemochromatosis are due to mutations in the HFE gene. The body absorbs excess iron and can deposit in different organs. Early lab clue is an elevated ferritin and high transferrin saturation

Ferritin

The Brain

Iron Metabolism