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Why is this ANP and BNP released from over worked /overloaded hearts. #acute and chronic heart failure? ANP - atrial natrietic peptide is a protein released from atrial cells when your heart is over stretched /over-preloaded/ or when you are fluid overloaded. Brain Natrietic Peptide is also released from atrial but mostly ventricular muscle under the same circumstances. ANP is faster to be released and activates in acute overload eg if we gave IV fluids too fast, or the patient develops an AKI a
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