HIV: Three trials to watch in 2024 - Clinical Trials Arena
Dec 18, 2023 · The Phase IIa trial (NCT05947890) is investigating the safety and immunogenicity of the vaccine candidate and primary completion is scheduled for November 2024. The study plans to enrol 276 patients and it will be conducted in two parts, A and B. Part A will include two cohorts; each cohort will have four groups.
Novartis’ atrasentan shows superiority in Phase III IgAN trial
Oct 30, 2023 · Novartis has reported positive topline data from an ongoing Phase III trial investigating atrasentan in patients with IgA nephropathy (IgAN). The 36-week interim analysis stated that the trial met its primary efficacy endpoint. Atrasentan demonstrated superiority compared to the placebo in reducing protein in urine, also known as proteinuria.
Alzheimer's trials: How does donanemab compare to lecanemab?
Jan 13, 2023 · Already, 2023 is shaping up to be an eventful year in Alzheimer’s disease (AD) drug development. After the FDA’s approval of Eisai/Biogen’s Leqembi (lecanemab) on January 6, the AD field is now looking toward the upcoming approval decision for Lilly’s donanemab expected in May. Although both donanemab and lecanemab have similar therapeutic targets, the two AD antibodies employed ...
Oral Covid vaccine: can Vaxart overcome clinical trial obstacles?
Nov 24, 2021 · Vaxart’s Covid-19 vaccine tablet has a coating that allows it to withstand the low pH in the stomach. Credit: Vaxart. Vaxart is aiming to be a vital player in boosting vaccination rates with its oral Covid-19 vaccine. There is still unmet need, with only 53% of the world’s population receiving at least one dose of a Covid-19 vaccine.
Obesity: Six trials to watch over the next 12 months
Jun 30, 2023 · According to a report by GlobalData, the market for obesity drugs is predicted to be worth $37.1bn in 2031. GlobalData is a parent company of the Clinical Trials Arena. As more trials take place globally, not only will this help to provide a wider range of treatments for patients but will also assist the unmet need of lack of supply.
Schizophrenia: Four major clinical trials to watch in 2023
Apr 13, 2023 · But in 2023, four late-stage clinical trial readouts in schizophrenia could offer a new glimmer of hope. Most currently available treatments for schizophrenia are traditional antipsychotics targeting the dopamine 2 and dopamine 3 receptors, explains Dr. Christopher Correll, psychiatrist at the Zucker School of Medicine at Hofstra/Northwell.
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Longboard commences Phase III trial of bexicaserin for DEEs seizure treatment. In the trial, participants will undergo a five-week screening period, followed by baseline evaluations.
Medicine in outer space: drug development, manufacturing, and …
Oct 6, 2022 · LASIK surgery, artificial limbs, cochlear implants, and infrared ear thermometers, among other healthcare innovations, all have their origins in NASA-funded research. The same could be true for the drug development and manufacturing industries, as the next era of research in aerospace medicine is sure to prompt unanticipated discoveries.
Top Ongoing mRNA Herpes Vaccine Trials - Clinical Trials Arena
Feb 2, 2023 · Pfizer and Moderna eye seasonal influenza. The two largest mRNA vaccine trials with readouts in 2023 are for seasonal influenza. First up, Moderna’s 6,102-patient, Phase III trial of mRNA-1010 (NCT05415462) has immunogenicity data expected in Q1 2023. The trial is testing mRNA-1010 against an active comparator vaccine, with primary endpoints ...
BioNTech treats first subject in Phase II cancer vaccine trial
Oct 20, 2023 · BioNTech has treated the first subject in a Phase II clinical trial of cancer vaccine candidate, autogene cevumeran (BNT122, RO7198457) to treat resected pancreatic ductal adenocarcinoma (PDAC), a type of solid tumour. Autogene cevumeran is a messenger ribonucleic acid (mRNA)-based individualised neoantigen-specific immunotherapy (iNeST) candidate.