Protein aggregation can occur due to a variety of causes. There are four classes that these causes can be categorized into, which are detailed below. Mutations that occur in the DNA …

Jul 1, 2023 · Protein aggregation studies are important to understand the mechanism behind the occurrence of various protein misfolding and aggregation diseases. Protein aggregation can …

Here, we will briefly review the composition and causes of protein aggregation in mammalian cells, systematically summarize the role of protein aggregates in the organisms, and further …

Sep 8, 2023 · Here, we review the current understanding of how intrinsic protein conformational propensities are modulated by physiological and pathological interactions in the cell to shape …

Dec 4, 2021 · To provide guidance on how to analyse protein aggregation, in this review we summarize the most commonly investigated aspects of protein aggregation with some popular …

Jul 8, 2025 · Protein aggregation refers to the spontaneous association of proteins into larger, nonnative structures, leading to the formation of aggregates with distinct physicochemical …

Oct 25, 2018 · This review is intended to summarize four major aspects of protein aggregation - (1) aggregation mechanisms, (2) aggregation-influencing factors, (3) detection of protein …

Jul 31, 2025 · Protein aggregation occurs when unfolded or partially folded protein molecules interact with each other, forming clusters or larger complexes. This process can be triggered …

Protein aggregation presents a significant challenge in the biopharmaceutical industry, affecting drug development by potentially reducing therapeutic efficacy and introducing immunogenicity …

Jan 19, 2026 · Protein aggregation is a critical phenomenon that occurs when certain proteins, rather than folding into a single, unique native conformation, adopt alternative, often misfolded …