A cruise to the Panama Canal is filled with country-hopping adventures that take you to Mexico's Mayan ruins, white beaches in Cabo San Lucas or Colonial treasures in Colombia.

The most popular time to cruise around Panama is from winter through spring. During these months, Princess offers a range of itineraries that transit the Panama Canal and visit ports throughout the …

Experience the marvel of the Panama Canal with NCL. Cruise this historic waterway, explore Caribbean cities, and discover lush Central American jungles.

From Huatulco’s beautiful beaches and delectable Oaxacan cuisine to Cartagena’s colonial-era fortress and massive city walls, every day brings a new adventure on Panama Canal cruises.

Take a cruise with Carnival to the iconic Panama Canal and stop in ports like Colon, Cartagena, and Puntarenas. Book your Carnival cruise today!

Discover the lush scenery around manmade Lake Gatun, listen to tales of pirates and conquistadors, and buy exquisite handicrafts made by Panama’s indigenous Emberá tribe. Other highlights include …

Traverse the Panama Canal on a Viking voyage. Discover vibrant cities and stunning landscapes as you keep watch for wildlife in crystal-clear waters.

Head to our website and book a cruise through the Panama Canal for a journey combining historical cities and unspoiled nature. Find out more!

Sail to Panama Canal in unmatched luxury. Crystal Cruises offers elegant suites, world-class dining, butler service, and immersive Caribbean experiences.