NRF2, a Transcription Factor for Stress Response and Beyond
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative …
NFE2L2 - Wikipedia
Both Gclc and Gclm are characteristic NRF2 target genes, which establish NRF2 as a regulator of glutathione, one of the most important antioxidants in the body.
Thirty years of NRF2: advances and therapeutic challenges
Mar 4, 2025 · Over the last 30 years, NRF2 has evolved from being recognized as a transcription factor primarily involved in redox balance and detoxification to a well-appreciated master regulator of cellular...
The Nrf2 Pathway: How It Works and Why It’s Important
Nov 26, 2025 · The Nrf2 pathway is a central biological process in health maintenance and the biology of aging, making it a major focus in longevity and disease prevention studies.
Advances and challenges in therapeutic targeting of NRF2
Jan 9, 2023 · In this opinion article we describe the rationale for targeting NRF2, summarise the recent advances in drug development of NRF2 modulators, and reflect on the remaining challenges in …
Understanding NRF2: Clinical Relevance in Oxidative Stress ...
Explore the NRF2 pathway's critical role in oxidative stress, inflammation, and chronic disease. Learn how NRF2 activation supports neuroprotection, cardiovascular health, and metabolic function—with …
What Is Nrf2 and Why Is It Important for Your Health?
Jul 24, 2025 · Nrf2 (Nuclear factor erythroid 2-related factor 2) is a protein in the human body that plays a significant role in cellular defense. It acts as a sensor, detecting various forms of stress within cells …
NRF2, a Transcription Factor for Stress Response and Beyond
Jul 6, 2020 · Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in …
JCI Insight - Nrf2 activator peptide protects the brain from ...
4 days ago · To accomplish this, we enhanced the endogenous activity of Nrf2 (nuclear factor E2-related factor 2) by treating with an Nrf2 activator III TAT peptide (Nrf2 peptide, NP) and investigated the …
NRF2 immunobiology in cancer: implications for immunotherapy ...
Sep 13, 2025 · Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that acts as a key regulator in cellular defense mechanisms against oxidative stress and xenobiotics.