MSU crystals are known to cause inflammation, [2] and clinically gout commonly presents as recurrent episodes of acute inflammation, frequently at the joints, but which can also involve …

Dec 12, 2024 · Hyperuricemia is the most important risk factor for gout and leads to deposition of monosodium urate crystals in various tissues and joints, leading to inflammation and …

Both the monosodium urate (MSU) crystals associated with gout and CPP crystals induce inflammation dependent on IL-1 beta, but IL-1 beta inhibitors have been investigated more as …

Dual-energy CT is a relatively new approach to gout diagnosis that could emerge as a useful adjunctive tool for certain hard-to-confirm cases.

Researchers have identified separate gut bacteria species that can metabolize purines and urate, suggesting that microbial pathways might be leveraged through probiotics to reduce …

Oct 27, 2025 · The drug colchicine may reduce cardiovascular outcomes among patients with gout, based on a range of retrospective data that suggest improved outcomes and mechanistic …

Jun 18, 2024 · Basing the treatment of gout on reaching and maintaining target serum uric acid level is already endorsed in guidelines, but a randomized trial finally showed the advantage …

Oct 27, 2025 · In patients with gout, a novel prediction tool that relies on weight and creatinine clearance successfully identified the dose of allopurinol required to achieve a serum urate …

Nov 7, 2025 · The ability to predict gout flares could enable prophylactic treatment.

Oct 29, 2025 · An expert in gout clinical trials questions whether ethical considerations for such trials need updating to emphasize patient choice, dose alterations, and anti-inflammatory …