If the Minnesota Vikings win, then this game will not have an impact on the Lions' ability to clinch. However, a Vikings loss ...

Here are the lines, spreads and totals for all 16 games on the Week 17 slate. Football Power Index (FPI) by ESPN Analytics.

San Francisco 49ers top scorers look to capitalize on opportunities early against Detroit Lions stout defense.

SportsLine expert Eric Cohen reveals his score predictions for the 14 remaining games in Week 17 of the NFL schedule ...

The Lions are used to rooting against NFC North rivals. But this weekend, they’ll also have to root for one of them.

The Lions will face a 49ers offensive line that could be starting two tackles signed off practice squads this week ...

The Detroit Lions and San Francisco 49ers met 11 months ago at Levi's Stadium with a trip to the Super Bowl on the line. San Francisco used a furious second half comeback to steal the NFC Championship ...

Find out what the San Francisco 49ers are saying as they prepare for their Week 17 matchup vs. the Detroit Lions.

San Francisco 49ers face a daunting Week 17 test against Detroit Lions with injuries threatening their ability to compete.

Mike Spofford and Wes Hodkiewicz break down the keys to the game as the Green Bay Packers face off against the Minnesota Vikings in an NFC North matchup at U.S. Bank Stadium.

Five of the seven playoff spots are taken in the AFC, with the Kansas City Chiefs clinching the conference's overall top seed with a 29-10 win over the Pittsburgh Steelers on Wednesday. In the NFC, ...