But here at ESPN bowl prediction headquarters in downtown Indianapolis, we're not afraid of any circumstances. So let's get to the picks, from campus CFP sites through traditional bowls and all the way to the national title game on Jan. 20 in Atlanta.

Penn State demolished SMU in Round 1, but despite a 38-10 win, the Nittany Lions only generated 325 yards on 18 first downs. I expect Penn State to win and advance, but I’ll go under the 53 total points.

Notre Dame’s defense set a dominating tone early in its College Football Playoff opener against Indiana. The Fighting Irish stuffed the highest-scoring team in the CFP field for a 14-3 halftime lead,

It is the first of the CFP quarter-finals as we continue our college football odds series with a Penn State-Boise State prediction and pick.