BACKGROUND: Exercise improves functional outcomes in patients with diabetic cardiomyopathy (DiaCM). The molecular mechanism ...

Total RNA was extracted using Trizol (Invitrogen), and the concentration ... We conducted GO and KEGG pathway analysis on genes with differential m6A methylation to more deeply explore the m6A ...

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China ...

their drug resistance is one of the major challenges in cancer therapy. In recent years, epigenetic modifications, especially N6-methyladenosine (m6A) RNA modifications, have become a hot research ...

When developing mRNA therapeutics, capping technology plays a crucial role in determining the stability, translation efficiency and immunogenicity of synthetic mRNAs. Advancements in ...

Led by Ryan Flynn, MD, PhD, assistant professor of stem cell and regenerative biology at Harvard Medical School (HMS), the study identified one RNA-binding protein on the cell surface, NPM1 ...

Additional data presented will underscore the potential of GRAIL's ctDNA-based targeted methylation assay for quantifying abnormal promoter methylation, which is a known hallmark of cancer and has ...

Edited by Zsuzsanna Zsengeller, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; received September 12, 2024; accepted March 8, 2025 by Editorial Board Member Carl F. Nathan ...

Yuen and colleagues reported on their study in Nature Neuroscience, in a paper titled, “Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis ...