This study designs a DNA logic gate system integrating nucleic acid aptamers, catalytic hairpin assembly (CHA), and CRISPR-Cas12a, pioneering its use for AML antigen detection. The system comprises ...

Regarding tumor exosomal miRNA detection, electrochemical biosensors are categorized based on signal amplification methods into nucleic acid-mediated signal amplification biosensors and ...

Department of Anesthesiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, 710038, China ...

Celyad Oncology (Euronext: CYAD) (the "Company"), today announces its financial results for the fiscal year ended December 31, 2024, and provides a business update. Matt Kane, ...

It's a big year for microRNAs. The 2024 Nobel Prize in Physiology or Medicine went to Victor Ambros and Gary Ruvkun, who discovered the first microRNA in 1993. Today, we know that humans make more ...

Endogenous siRNAs exist and differ from miRNAs in that they are not derived from primary miRNA transcripts, and they do not undergo canonical miRNA processing. Rather, they can be derived from long ...

Here, we performed small-RNA sequencing across 212 mid-gestation human neocortical tissue samples, measured 907 expressed miRNAs, discovering 111 of which were novel, and identified 85 ...

Global analysis of miRNA–target gene interactions identified two sub-network modules, the first organized in upregulated miRNAs connected with downregulated target genes and the second with opposite ...

Processing of introns from the overlapping primary miRNA (pri-miRNA) transcripts generates a hairpin structure that can be further processed by Dicer-like 1 (DCL1). The mature nat-miRNAs typically ...