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A new class of antivirals could help prevent future pandemicsa multifunctional enzyme with methyltransferase activity. Those compounds then went through an extensive chemical developmental process to create optimized drug candidates in partnership with the ...
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The battle between resilient plants and cunning viruses: Study discovers a novel RNA silencing mechanismMore information: Zhao-Jun Pan et al, HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1, Nature Communications (2025). DOI: 10.1038/s41467-025-56320-z ...
The sensitivity of the aptamer (measures SAH at concentrations below 10 nM), allows detection of methyltransferase activity at physiological concentrations of SAM. The unique direct detection ...
The WD40 protein WDR5 is a core subunit of the human MLL and SET1 (hCOMPASS) histone H3 Lys4 (H3K4) methyltransferase ... promoting complex assembly and activity. These findings suggest that ...
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