Using mammalian cells and fission yeast, these two groups built on findings that histone methyltransferase SU(VAR)3-9 and its yeast homolog, Clr4, specifically methylate the ninth lysine (K9) on ...

Histone deacetylation and other modifications, particularly the methylation of lysine 9 within histone H3 (H3-K9) residues located in the histone tails, cause chromatin condensation and block ...

Lymphomas belong to the group of malignant diseases of the immune system and mainly affect the organs of the lymphatic system ...

while transcriptionally inactive chromatin was associated with K9 methylation. While this study supports the existence of gene regulation by a histone code, many more exciting questions remain.

Discover how histone modifications unlock secrets of human aging, rivaling the precision of DNA methylation in decoding biological age. In a recent study published in the journal Science Advances ...