Although not designed to eliminate experiments, the model, which is intended to accelerate process development, can reduce the number needed.

Researchers have developed a new technology that allows accurate visualization of the different parts that make up a single ...

Several human pathogens exploit the kinetic forces generated by polymerizing actin to power their intracellular motility. Human cell-autonomous immune responses activate ...

Hela cells were co-transfected with YFP-nsp16(yellow ... The mutated nsp16 plasmids were transfected into HEK293T cells. After 36 hours of culture, cells were treated with 10 µm MG132 or DMSO, ...

Design We integrated a combination of newly established preclinical models of FLC and an unbiased polypharmacology-based approach to identify downstream kinases involved in DNAJ-PKAc-mediated FLC cell ...

We thank Yi Chun Hsiung for assistance with cell culture, George Vaisey for advice, and all MacKinnon Lab and Chen Lab members for helpful discussions. We thank Mark Ebrahim, Johanna Sotiris, and ...

This review provides an overview of recent research advancements on the functional roles of ECs in islet biology, transplantation, and in vitro islet organoid culture. In 2006, Johansson et al.