Recently, I have generated a transgenic mouse model for a skeletal muscle disease, the Laing distal myopathy. These mice carry a single arginine to proline mutation in the β-myosin rod domain and now ...

Administering sialic acid metabolites to mice with distal myopathy with rimmed vacuoles (DMRV)–hereditary inclusion body myopathy (hIBM) prevents the onset of muscle atrophy, weakness and ...