A woman in her 50s with genetically confirmed Huntington’s disease presented with right-sided arm sensory symptoms that evolved over days and persisted for at least 1 month. Neurological examination ...

News and commentary from the world of neurology and neuroscience ...

We used 2 mouse models of established cardiac fibrosis induced by administration of isoproterenol (30 mg/kg per d SC) for 1 week with animals studied 4 weeks afterwards, or transgenic overexpression ...

Metabolic reprogramming in fibrotic lung diseases involves key metabolites like lactate, succinate, and 2-hydroxyglutarate, driving inflammation and fibroblast activation. Lactate accumulation ...

MS patients have increased risks of developing other autoimmune diseases, necessitating careful treatment planning to balance efficacy and risk. Dimethyl fumarate, anti-CD20 antibodies, and ozanimod ...

Fumarate-based therapies like Tecfidera (dimethyl fumarate) and Vumerity (diroximel fumarate) are equally effective among Black, Hispanic, Asian, and white adults with relapsing forms of multiple ...

Friedreich's ataxia (FA) is a genetic disorder caused by a severe decrease in FXN (frataxin) protein expression in mitochondria. The clinical manifestation of this disorder is a cerebellar ataxia; ...

Tecfidera’s (dimethyl fumarate) usual dosage for MS and CIS is 120 mg twice per day for 7 days, and then 240 mg twice per day. Tecfidera treats the following conditions: relapsing-remitting multiple ...

The anti-inflammatory drug dimethyl fumarate (DMF) may help repair cell energy systems and restore immune balance in the gums to reverse damage from periodontitis, according to a news release dated ...