Aortic regurgitation can result from abnormalities of the aortic valve leaflets, dilation of the aortic root, or a severe increase in afterload. When the aortic leaflets are involved, there is ...

Mildly to moderately dilated ascending aorta showed a generally ... was the only factor associated with faster progression. At baseline, the aortic root and tubular ascending aorta diameters ...

Bramel et al, Intrinsic GATA4 expression sensitizes the aortic root to dilation in a Loeys–Dietz syndrome mouse model, Nature Cardiovascular Research (2024). DOI: 10.1038/s44161-024-00562-5 ...

Aortic regurgitation occurs when blood flows retrograde (backwards) across the aortic valve from the aorta into the left ventricle during diastole. This abnormal backflow of blood leads to ...