The study revealed that R-loops and their regulator RNase H1 are present at centromeres ... by phosphorylating kinetochore proteins such as HEC1. Dysregulation of Aurora B activity leads to abnormal ...

identical halves of the chromosome created when DNA is copied in preparation for cell division during mitosis. The chromatids, joined at the centromere, are several centimeters long, but compacted ...

They appear to play a major role in genetic variation among apes, including dramatic restructuring of large portions of the chromosomes ... and evolution of the centromere regions at the level ...

kinetochore assembly, the spindle assembly checkpoint, chromosome congression and chromosome segregation, ranging from kinetochore motors, centrosomal proteins, kinetochore complex proteins ...

Centromeres are specific sites on chromosomes that are essential for ... interest to those studying cell division and chromosome segregation. Previously, we reconstituted a minimal functional ...

Normally, researchers decode a chromosome by sequencing short segments and piecing them into a single string at points where their sequences overlap, just as someone completing a jigsaw puzzle might ...

The synaptonemal complex is an evolutionary conserved meiosis-specific protein complex that ensures the fidelity of the chromosome segregation process in germ cells. Despite the central biological ...

Considered as an entity, the eukaryotic complexes cohesin, condensin and the Smc5/6 complex control most chromosome-based processes, including replication, segregation, repair and transcription. While ...

which is necessary for faithful chromosome segregation. Centromeres are the site of assembly of the kinetochore, a proteinaceous structure that directs chromosome segregation during cell division.

Our findings also indicate a specific role for H2A.Z.1 in regulating the deposition of heterochromatin epigenetic hallmarks within PCH that likely maintain the fidelity of chromosome segregation and ...