Saunas and hot yoga offer therapeutic heat exposure, enhancing cardiovascular health, brain function, and psychological well-being through ancient practices.

The ER is an essential sensing organelle that provides multiple functions, including protein synthesis, folding, and secretion of almost one-third of all proteins in eukaryotic cells. In addition, the ...

The Harvard professor is pursuing fundamental questions about autophagy, protein homeostasis, and other cellular processes, and he’s always on the lookout for his next new topic. A series of rodent ...

ALPK3 (α protein kinase 3) is an atypical kinase highly expressed in human and murine hearts. Biallelic loss‐of‐function mutations in ALPK3 lead to pediatric cardiomyopathy. The specific stages at ...

Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093, United States Artie McFerrin Department of Chemical Engineering, Texas A&M University, College ...

Homeostasis: Cellular homeostasis is the maintenance of a stable internal state in cells despite external changes. It includes the regulation of proteins, pH, ion concentration and energy balance.

The molecular mechanism responsible for this unfolding process is not known; chaperones (proteins that help other proteins to acquire their most stable conformation) have been called into question ...

Aging is inevitable for most cell types in the human body, but hematopoietic stem cells (HSCs) seem to defy the process. They retain their self-renewing ability almost throughout an organism’s ...

In essence, the maintenance of protein homeostasis is a critical aspect of life. The proteostasis machinery, comprising molecular chaperones, the ubiquitin-proteasome system and other components, ...

Alzheimer’s disease (AD) is characterized by changes in protein homeostasis which leads to accumulation and aggregation of proteins that are toxic to cells in the brain. In AD, these include amyloid ...

HSP90 is also a mediator of cellular homeostasis ... and stop the chaperone cycle, leading to client protein degradation. Because of the HSP90 client repertoire, HSP90 inhibitors may combat ...