In neurodegenerative diseases such as Alzheimer's or Parkinson's, proteins accumulate in the body's cells, fold incorrectly and clump together to form larger aggregates. Normally, cells are able to ...

The authors confirm that telomeres in telomerase-positive cells terminate with 5'-ATC in a Pot1-dependent manner, and demonstrate that this principle holds true in telomerase-negative ALT cells as ...

Reaction kinetics describes rate dynamics in chemical and biological systems. It allows for the experimental determination of reaction rates, from which rate constants may be estimated, in order ...

We are grateful to Dr. Lina Xu [Metabolomics and Lipidomics Center-National Protein Science Facility (Beijing), Tsinghua University] for metabolic flux analyses; Dr. Xiaoyan Liu and Dr. Zhengguang Guo ...