Scientists have uncovered more than 20 genes whose mutations cause familial forms of Parkinson's disease. One of these genes ...

Using a novel method that gives a readout of which proteins are in specific locations within cells, UT Southwestern Medical ...

In the cytosol, the refluxed proteins remain in protein complexes with cytosolic chaperones (Igbaria et al ... reside within the ER membrane with a J-domain facing the cytosol (Piette et al., 2021; ...

SELENOT is a selenocysteine-containing protein of the ER membrane with antioxidant and neuroprotective activities, but its pathophysiological role in dopaminergic neurons remains unclear. In this ...

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institution, Fudan University, Shanghai 200438, China ...

Oct. 24, 2022 — Membrane proteins are key targets for many drugs. They are located between the outside and inside of our cells. Some of them, called 'transporters', move certain substances in ...

Morbidity and mortality of heart failure with preserved ejection fraction (HFpEF) is increased in metabolic disorders. However, options for preventing and treating these prevalent outcomes are limited ...

The research aims to identify key molecular and mutational events in thyroid, adrenal and other endocrine tumors, and their clinical applications in endocrine pathology and molecular pathology for ...

WIPI2 interacts with components of ULK1/2 complex and phosphatidylinositol-3-phosphate and this interaction tethers phagophore to the ER (Zhao et al., 2017). Vacuole membrane protein 1 (VMP1), an ...