NADK tetramer defective mutants confer chemotherapy resistance Mutations in the N-terminal region of cNADK promote tumor progression and chemotherapy resistance Peer-Reviewed Publication ...

Subsequently, 200 pmol of mono-SPYtag-avidin tetramer was added to the beads in 200 µL of EM buffer A, and the mixture was incubated at 4 °C for 10 h. Again, the beads were washed by collecting them ...

The FDA has approved BridgeBio's Attruby to treat cardiomyopathy. With the nod, BridgeBio will challenge Pfizer’s powerhouse Vyndaqel franchise.

Nevertheless, because glycoproteins are heterogeneous entities, it remains unclear how glycosylation modulates the protein structure and function. Here, we assess the ability of tandem-trapped ion ...

Scientists have identified a molecular intermediate of a serotonin receptor that is involved in diseases such as depression and schizophrenia. The study points to a potentially new target for ...

e15101Background: GD2-SADA is a bispecific fusion protein with binding domains for the tumor-associated antigen GD2 and Lutetium 177 (Lu-177)-DOTA complex, and a p53-derived domain that mediates ...

The change of amyloid nucleation may have an impact in the development of future therapeutic strategies for Huntington disease (HD), a study found.

The potential for personalized cancer treatment is fueling the need to identify T cell responses against neoantigens and other cancer-specific epitopes for the success of immunotherapy. Continuous ...

The formation of the 3D-DS tetramer can help prevent protein aggregation by decreasing flexibility, potentially avoiding the formation of insoluble aggregates. On the other hand, 3D-DS may promote ...