Christian McCaffrey made his season debut on Sunday, and his return could not have come at a better time. The San Francisco ...

The 49ers designated McCaffrey (Achilles) to return from injured reserve Monday. The move officially opens McCaffrey's 21-day practice window, and he's expected to be on the field Monday.

The 49ers placed Aiyuk (knee) on injured reserve Wednesday. Aiyuk has a long rehab path ahead of him after suffering ACL and MCL tears in his right knee during Sunday's loss to the Chiefs.

The Dallas Cowboys (3-4) mounted a fourth-quarter comeback against the San Francisco 49ers (4-4) that gave them the football down six with three minutes left in the game, but they were unable to ...

A good chunk of the chatter has been on potential reunions with players that used to suit up in red and gold. D.J. Jones ... add some quality depth to this 49ers attack," per Jones-Drew.

Regardless of who suits up in the red and gold on Sunday, it better be enough to beat the Cowboys who are without Micah Parsons. If you've noticed a lot of fresh faces when the 49ers are on the ...

Just like last year, the San Francisco 49ers are spinning with some October funk. A year ago, Kyle Shanahan’s team took a three-game losing streak into a Week 9 bye, then came back to rip off a ...

The NFL issued an $11,255 fine to San Francisco 49ers defensive end Nick Bosa for ... Bosa interrupted to point to a white and gold hat with "Make America Great Again" on the front.

The star wideout has been hospitalized with a “pneumonia-like illness,” according to 49ers head coach Kyle Shanahan. Samuel, who has 20 receptions for 335 yards and two touchdowns on the ...

And they’ve overcome worse. — Read more from Michael Silver Catch up on what you need to know from this week on the 49ers: Deebo Samuel and George Kittle questionable, Jauan Jennings out ...