Molecular chaperones are the central players that regulate the cell's repertoire of folded proteins, and as a consequence chaperones influence virtually every cellular process under both healthy and ...

To accomplish this, cells have evolved a sophisticated network of protein quality control machines consisting of molecular chaperones and energy-dependent proteases, which monitor the protein folding ...

Researchers have identified a potential strategy to protect against Alzheimer’s by increasing the clusterin (CLU) protein, ...

Heat shock protein 90 (HSP90) is a molecular chaperone of numerous oncoproteins. Therefore, cancer cells can be considered to be 'addicted' to this molecule. HSP90 is also a mediator of cellular ...

In recent years, there has been a growing trend of an aging patient population and an increasing prevalence of age-associated diseases, underscoring the need for advancing research into the biological ...

Park's laboratory studies the biogenesis of a molecular machine known as the proteasome ... via revealing conserved novel assembly chaperones for regulating assembly of the heterohexameric ATPase ...

He then worked for eight years as a Postdoctoral Researcher in the laboratory of Professor Michael Cheetham at the UCL Institute of Ophthalmology, where he researched the cell biology of molecular ...