Taste, pain, or response to stress -- nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers have uncovered the ...

Sterols are among the most abundant lipids in eukaryotic cells, yet are synthesized through notoriously long, complex metabolic pathways. Researchers have used a novel approach to show how they ...

Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes ...

ADAM19 appears to play a significant role in reducing the inflammatory response associated with intestinal damage and ...

Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.

Reelin and CTGF are distinctive markers for OECs Reelin is a developmentally expressed protein detected in specific neurons, in addition to OECs and Schwann cells. The canonical Reelin-signaling ...

Collagen, often likened to the body's glue, is a structural protein that forms the foundation for your skin, joints, bones, muscles, tendons, and even your gut lining. However, this vital protein ...

Mathew Blurton-Jones and his team at the University of California, Irvine, have engineered human iPSC-derived microglia (iMG) to ferry protein therapeutics into the brain. They CRISPR-engineered the ...

The novel approaches enabled the identification of many different proteins that modulate lysosomal organelle function and allowed the investigators to focus on a particular pathway that regulates many ...