Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and ...

10-amino-acid sequence called the "passport sequence," which facilitates the efficient trafficking of glycoproteins through the secretory pathway. When attached to target proteins, this sequence ...

When your body senses something is wrong—whether it's a damaged cell or a growing tumor—it can react in many ways. One of the most powerful is cellular senescence. This process stops a cell from ...

Bayer today announced that the U.S. Food and Drug Administration (FDA) has granted full approval for VITRAKVI® (larotrectinib), a first-in-class TRK inhibitor for the treatment of adult and pediatric ...

One possible stressor that may induce cell senescence is nuclear DNA damage, primarily in the form of DNA double-strand breaks (DSBs) that activate the DNA damage response (DDR) pathway.

A protein that stops cells from dividing in response to damage or stress could be a new biomarker or therapeutic target for ...

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...

The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a ...

Calcium transport into and out of mitochondria -- the powerhouses of cells -- is central to cellular energy production and cell death. To maintain the balance of calcium within these powerhouses, ...