Our kidneys normally maintain acid-base balance by removing acid and reabsorbing bicarbonate. In CKD, this function declines, ...

To increase the clinical benefits of bicarbonate supplementation, this intervention would need to be extended to patients with serum bicarbonate concentrations >20 mmol/l, but the safety of such ...

One investigation, utilising a large hospital cohort, identified low serum bicarbonate at admission as an independent risk factor not only for the development of acute kidney injury but also for ...

Patients with severe ketoacidosis typically present with a bicarbonate level <10 mEq/l and/or a pH <7.0, have total serum osmolality >330 mOsm/kg, usually present with mental obtundation, and are ...

The cell NAD+/NADH ratio can constrain biomass synthesis and influence proliferation in nutrient-limited environments. However, which cell processes regulate the NAD+/NADH ratio is not known. Here, we ...

The serum electrolytes were normal, ... After an additional 88 milliequiv. of sodium bicarbonate, without any additional epinephrine, the pH was 7.37, ...

This valuable manuscript investigates the localisation of nutrient receptors in bloodstream stage trypanosomes, with implications for both nutrient uptake and immune evasion. Results after direct ...

However, serum bicarbonate decreased from 24 to 19 mEq/L (below the normal range of bicarbonate, 23–29 mEq/L, indicating low-grade metabolic acidosis). To summarise, human studies have confirmed that ...

Aim this hospital review was to compare the effect of balanced versus unbalanced fluid bolus therapy on the mean change in serum bicarbonate and pH within 24 hours in children with Diabetic ...

Chronic kidney disease (CKD) is typically associated with severe fibrosis, the exact pathogenesis of which remains unclear.