This enzyme's selectivity for RNA, its high methylation activity ... an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency, Nucleic Acids Research (2024).

The authors designed elegant experiments to confirm the METTL3 works through genomic DNA, adding the methylation into DNA (6mA) but not the RNA (m6A), in this base damage repair context. The authors ...

The subsequent symptom of advanced DCM is heart failure. The present study focused on the role and mechanism of RNA methylation modifications (m6A, m5C, and m1A) in DCM, aiming to uncover shared ...

RUNX3 is identified as a critical transcription factor influencing lung development and inflammation, while changes in DNA methylation and histone dynamics in cord blood are linked to immune ...

Besides the existence of m6A in mRNA, the detectable incidence ... accept tRNAs but also other RNAs (including mRNAs) as methylation substrates, which in combination account for most of the RNA ...

The yeast RGG motif-containing RNA binding protein Scd6 and its human ortholog LSM14A regulate the translation of specific ...

The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting hepatic synthesis of lipoprotein(a), are unknown. We randomly assigned participants in a 1:2:2:2:2 ...

A new private-public partnership, 20,000-seat stadium, units for 10,000 athletes and even a multistorey horse pavilion – step inside the cutting edge transformation of the RNA Showgrounds.

“When I did the review I met with RNA officials and it was glaringly obvious it needed a facelift. “It just wasn’t going to work (as the main stadium) within the budget framework and ...