Using mammalian cells and fission yeast, these two groups built on findings that histone methyltransferase SU(VAR)3-9 and its yeast homolog, Clr4, specifically methylate the ninth lysine (K9) on ...

Histone deacetylation and other modifications, particularly the methylation of lysine 9 within histone H3 (H3-K9) residues located in the histone tails, cause chromatin condensation and block ...

Discover how histone modifications unlock secrets of human aging, rivaling the precision of DNA methylation in decoding biological age. In a recent study published in the journal Science Advances ...