In April 2025, Kamau Therapeutics announced a study is a first-in-human, single-arm, open-label Phase I/II study of nula-cel ...

Variations in inflammation may contribute to vaso-occlusive events (VOEs) during the menstrual cycles of women with SCD, per ...

The classic view of sickle cell disease pathophysiology involves polymerization of mutated hemoglobin (HbS) leading to red blood cell (RBC) sickling with subsequent hemolytic anemia, painful ...

Sickle Cell Disease is a genetic blood disorder that affects hemoglobin ... Additionally, chronic inflammation, hemolysis (the breakdown of red blood cells), and poor circulation can further weaken ...

Hydroxyurea Significantly Reduces Infections in Children With Sickle Cell Anemia Jan ... 2022 — The destruction of red blood cells, or mechanical hemolysis, is an inevitable complication ...

There are many possible causes of hemolytic anemia, including certain medications and inherited conditions like sickle cell disease and thalassemia. Depending on the cause, the treatment may involve a ...

A condition called hemolytic anemia occurs when red blood cells break ... or inherited conditions like sickle cell disease. To treat anemia, your doctor may recommend taking iron supplements ...

In human cells, heme is always bound to proteins due to its toxic nature. However, free heme can be present within tissue and in the bloodstream as a consequence of hemolysis or under pathological ...

Hydroxyurea remains effective over the long term among children with sickle cell disease, real-world data suggested. The ...