It may also indicate a complication of leukemia known as extramedullary disease (EMD). EMD occurs when leukemia involves several organ systems, such as the skin, lymphatic system, nervous system ...

Characterizing normal hematopoiesis is critical to determining how this process is disrupted, leading to AML. However, current reference maps for normal hematopoiesis are imprecise or based on small ...

More than 25% of adults in North America have dietary copper intake below the estimated average requirement of 0.7 mg/d1 Copper plays key roles in hematopoiesis, iron metabolism, and maintenance of ...

Understanding the biological interface of age-related genetic changes and diseases of aging, such as cancer and cardiovascular disease, is important to develop preventative therapies for a growing ...

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele ...

Tumor-infiltrating clonal hematopoiesis increased the risk of disease recurrence or death among patients with cancer. TET2 mutations were the strongest genetic predictor of tumor-infiltrating ...

Clonal hematopoiesis of indeterminate potential (CHIP) is a condition where blood stem cells accumulate mutations over time, influenced by both aging and external environmental factors.

Clinical Impact of Somatic Genomic Variants of Oncogenes and Tumor Suppressor Genes in Previously Treated Advanced Non–Small Cell Lung Cancer The following represents disclosure information provided ...

This important study advances our understanding of maladaptive innate immune training. The experimental evidence supporting the conclusions is convincing and the expert reviewers strongly endorse the ...

However, so far, we have limited knowledge about the critical molecular pathways mediating the protective interactions of LSCs with their niches in the BM and tissues outside BM, so-called ...