In the recent article, “Antisense Oligonucleotide Therapy for Calmodulinopathy,” we provided the first proof-of-concept in ...

The technology is genuinely useful for scientific discovery, but its applications are less dramatic than you might think.

The findings suggest that lipid metabolism may play a central role in maintaining a healthy immune system as we age. The researchers analyzed gene and protein ... the complement of lipids changes ...

Amyotrophic lateral sclerosis (ALS) is a relatively rare but very serious disease of the nervous system. A cure is not ... In ALS, poorly soluble protein aggregates accumulate in motor neurons.

But it’s thought to involve the medication’s ability to block the activity of a complement system protein called C5 at the neuromuscular junction (NMJ). The NMJ is where nerve cells ...

The researchers found that the activation of NLRP3 and AIM2 inflammasomes—proteins in immune cells that detect threats and trigger a response—is a key factor in severe inflammatory responses ...

The complement system consists of more than 30 proteins found in plasma and on cell surfaces, which enhance the activity of antibodies and phagocytic cells in removing microbes, immunocomplexes, and ...

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, United States ...

Attribution (BY): Credit must be given to the creator. In contemporary studies on the role of the protein corona in specific biological applications, identifying correlation is widely used to draw ...