The study revealed that R-loops and their regulator RNase H1 are present at centromeres ... by phosphorylating kinetochore proteins such as HEC1. Dysregulation of Aurora B activity leads to abnormal ...

More specifically, this case involves the non-reciprocal translocation of the centromere and stalk of an acrocentric into 12p, generating an apparently stable dicentric chromosome ... DA/DAPI ...

Yao's lab is trying to understand how faithful chromosome segregation is orchestrated during cell division. Over the years, they sought to delineate how dozens of centromere proteins assemble into a ...

identical halves of the chromosome created when DNA is copied in preparation for cell division during mitosis. The chromatids, joined at the centromere, are several centimeters long, but compacted ...

They appear to play a major role in genetic variation among apes, including dramatic restructuring of large portions of the chromosomes ... and evolution of the centromere regions at the level ...

We thank members of the Henikoff laboratory and Sue Biggins for insightful discussions. S.H. is an Investigator of the HHMI. This work was supported by NIH Grant HG012797 to Y.Z. Reviewers: K.S.B., ...

The last few years have provided us with a new level of understanding of how chromosomes are replicated, segregated and read - and how their 3D organisation influences expression of individual genes ...

Considering its functions in centromere stability and DNA repair, investigating HJURP’s role in GC may offer novel therapeutic perspectives. Methods: HJURP expression was examined in a dataset ...