We thank members of the Henikoff laboratory and Sue Biggins for insightful discussions. S.H. is an Investigator of the HHMI. This work was supported by NIH Grant HG012797 to Y.Z. Reviewers: K.S.B., ...

The last few years have provided us with a new level of understanding of how chromosomes are replicated, segregated and read - and how their 3D organisation influences expression of individual genes ...