Interaction of nascent secretory proteins in the ER with molecular chaperones, such as BiP or ... kifunensine blocked degradation of both the membrane and the secreted forms of immunoglobulin ...

Dynamic remodeling of the endomembrane system is a core biological process essential for maintaining cellular ...

This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

Therefore, cells have mechanisms in place to control protein quality. In animal and human cells, chaperones of the ...