In the cytosol, the refluxed proteins remain in protein complexes with cytosolic chaperones (Igbaria et al ... reside within the ER membrane with a J-domain facing the cytosol (Piette et al., 2021; ...

Quarantining aggregating proteins in membrane-less compartments is a widely accepted ... They show the involvement of the ER, ATPase-dependent, BiP chaperone, and the requirement of Cdk1 inactivation ...

Membrane protein production has long been a technical challenge, often resulting in misfolded or inactive proteins. eProtein Discovery overcomes these challenges, enabling scientists to rapidly ...

Nuclera, announced the addition of a new membrane protein workflow to its system. This expanded capability enables the expression, purification and stabilization of challenging membrane proteins, ...

Using a novel method that gives a readout of which proteins are in specific locations within cells, UT Southwestern Medical ...

Scientists have uncovered more than 20 genes whose mutations cause familial forms of Parkinson's disease. One of these genes ...

Oct. 24, 2022 — Membrane proteins are key targets for many drugs. They are located between the outside and inside of our cells. Some of them, called 'transporters', move certain substances in ...

Nuclera, a Cambridge biotech accelerating protein expression and optimisation, has added a new membrane protein workflow to its benchtop eProtein Discovery™ system. The expanded capability enables the ...

Nuclera, the biotechnology company accelerating protein expression and optimization through its benchtop eProtein Discoverytm system, today announced the addition of a new membrane protein ...