Apnimed, Inc., a pharmaceutical company building the industry-leading portfolio of first-in-class oral drug candidates that address the root causes of obstructive sleep apnea (OSA) and other ...

Apnimed has announced The Lancet has published positive results from the Phase 2 FLOW study evaluating sulthiame, a differentiated, once-daily oral carbonic anhydrase inhibitor, in the treatment of ...

In a recent study published in Nature Chemical Biology, University of Cambridge scientists used zebrafish models of tauopathies — a group of neurodegenerative diseases driven by tau protein ...

Comparison of Menopausal Symptoms During the First Year of Adjuvant Therapy With Either Exemestane or Tamoxifen in Early Breast Cancer: Report of a Tamoxifen Exemestane Adjuvant Multicenter Trial ...

This is a preview. Log in through your library . Abstract ABSTRACT Carbonic anhydrase activity in the extracellular fluid of lower vertebrates is considered to be minimal, either because of the ...

Carbonic anhydrase inhibitors (CAIs) have long represented a versatile class of agents in clinical medicine. By targeting the zinc metalloenzymes responsible for rapidly converting carbon dioxide to ...

Carbonic anhydrases are mostly zinc metalloenzymes that catalyze the reversible hydration/dehydration of CO₂/HCO₃⁻. Previously, the X-ray crystal structures of CO₂-bound holo (zinc-bound) and apo ...

DELRAY BEACH, FL / ACCESSWIRE / May 16, 2023 / Adolore Biotherapeutics, Inc. ("Adolore" or the "Company") a biotechnology company focused on developing breakthrough opioid-free pain relieving ...

To the Editor: The paper by Kleinman et al., "Blood Carbonic Anhydrase Acitivity and Zinc Concentration in Infants with Respiratory-Distress Syndrome" (New Eng. J. Med. 277: 1157–1161, 1967), raises ...

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in ...