pharmaphorum

Update: FDA clears first generic of AZ's blockbuster Symbicort

Viatris (formerly Mylan) has become the first drugmaker to win full FDA approval for a generic version of AstraZeneca's top-selling respiratory drug Symbicort, although launch plans remain uncertain ...
American College of Cardiology

Eagle’s Eye View: Beta-Blocker vs. Calcium-Channel Blocker in HCM

In this week’s View, Dr. Eagle looks at the differential effect of bisoprolol versus verapamil in nonobstructive hypertrophic cardiomyopathy (HCM) treatment. He then explores lower heart failure (HF) ...
BMJ

BS13 Unravelling the dual role of fumarate as an intracellular and extracellular hypoxia-induced signalling molecule in human cardiomyocytes

Fumarate is a Krebs cycle intermediate involved in energy generation. However, metabolites can also act as signalling molecules, regulating cell function. Here we identify novel intracrine and ...
American College of Cardiology

REDUCE-AMI: Long-Term Beta-Blockers May Not Lower Risk of Death, MI in Patients With MI, Preserved LVEF

Long-term treatment with beta-blockers may not lower the risk of death or myocardial infarction (MI) in patients with MI, a preserved left ventricular ejection fraction (LVEF) of ≥50% and coronary ...