Sorbonne Université, Laboratoire de Chimie Théorique, UMR 7616 CNRS, 75005 Paris, France Equipe Structure et Interactions des macromolécules, UR EGP, Centre d’Analyses et de Recherche, Faculté des ...

This means there are 2.447 billion positions in the DNA filled by one of the four nucleotides: adenine, thymine, cytosine, and guanine. The order in which these four nucleotides appear determines ...

DNA methylation profiling tracks chemical changes at specific cytosine-phosphate-guanine (CpG) sites in the genome to estimate biological age. Well-established models like the Horvath and Hannum ...

These compounds prevent guanine nucleotide exchange factor (GEF)-mediated activation, inhibiting downstream signaling through the RAF-MEK-ERK cascade. This patent application introduces a new class of ...

The DNA glycosylase MutY, which is a member of the Helix-hairpin-Helix (HhH) DNA glycosylase superfamily, excises adenine from mispairs with 8-oxoguanine and guanine. High-resolution crystal ...