They graphically represent the life cycle of HIV-1, from the initial binding of the viral particle onto a host cell (Viral Entry), through insinuation into the host cell's nucleus to spark the ...

In July 1 advanced online Nature Immunology, Lisa Matthias and colleagues at the University of New South Wales, Sydney, Australia, show that disulfide exchange in domain 2 of CD4 is required for entry ...

The trimeric, α-helical coiled-coil core of the HIV-1 ... mediated cell fusion. Figure 1: Stereo view of contacts near the N-terminus of the outer helix of gp41. Figure 2: A structure-based ...

Entry inhibitors are a class of drugs that block HIV from entering CD4 T cells. These inhibitors include: enfuvirtide (Fuzeon), which belongs to the drug class known as fusion inhibitors maraviroc ...

HIV-1 entry into cells is an attractive target for new antiviral agents. But will inhibitors aimed at the CCR5 co-receptor force HIV-1 to evolve more virulent forms? Other targets for entry ...