Myeloid cells, a type of white blood cell, originate in the bone marrow and circulate "peripherally" in the blood; the same is true for mutant myeloid LCH precursors. "These novel mechanistic insights ...

Our blood consists of many cell types that develop through different stages from a precursor type—the blood ... and the large group of white blood cells that orchestrate the immune defense.

There may be a link to autoimmune diseases, genetics, or environmental factors. Like multiple myeloma, MGUS starts in a type of white blood cell called plasma cells. These cells make m-protein. This ...