Tumour heterogeneity describes differences between tumours of the same type in different patients, and between cancer cells within a tumour. Both can lead to different responses to therapy.

Raleigh, MD, Ph.D., the Robert and Ruth Halperin ... "We know that intratumoral heterogeneity is a driver of resistance to cancer therapies, and so we hypothesized in this study that intratumoral ...

2014;9(3):487-499. pH-responsive nanoparticles that reverse surface charge or expose ligands such as TAT and biotin at the outer surface ('deshielding') at tumor pH have been developed to ...

The Tammela lab is interested in understanding the remarkable phenotypic heterogeneity of cancer cells within tumors. We approach this question using a combination of sophisticated genetically ...

Such flexibility underscores the profound intratumour heterogeneity characteristic of pancreatic cancer, where myriad ... co-first author and a former Ph.D. student at the University of Verona.

"What's interesting is that there is a lot of heterogeneity ... Ph.D. student in Engler's lab. "Among DCIS patients, for example, we found some with strongly adherent tumor cells and others ...

computational methods for identifying biomarkers of tumor heterogeneity. Parvin's Lab, at LBNL, received an R&D100 award in 2014 for the development of BioSig3D. BioSig3D is the first system for high ...

Tuomas Tammela, MD, PhD Cancer biologist Tuomas Tammela investigates cellular heterogeneity in lung and pancreatic cancers. Craig B. Thompson, MD Craig Thompson studies molecular signaling pathways ...

These models are being used to study critical questions of tumor heterogeneity, dormancy and recurrence with a focus on the treatment of metastatic triple negative breast cancer. The research ...