After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

WHEN WE HUMANS got a first glimpse of our genome, we had good reason to question our biological complexity. Many scientists predicted we would possess some 100,000-plus genes, but sequencers finally ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell. The ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 19 (May 10, 2016), pp. 5447-5452 (6 pages) Protein arginine methylation, catalyzed by protein arginine ...

In a recent paper, a team of researchers explain how the molecular machine known as the spliceosome begins the process of rearranging gene sequences in RNA splicing. Certain diseases such as cystic ...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--H3 Biomedicine Inc., a clinical stage biopharmaceutical company specializing in the discovery and development of next generation cancer therapies using its data ...

A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic ...

A new imaging technique can be used to understand the workings of complex biomolecular processes at a more detailed level than previously possible. The technique marks biomolecules with organic dyes ...

Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a ...