Serine hydrolases use a conserved nucleophilic serine to hydrolyze ester, amide or thio-ester bonds in proteins and small molecules and constitute one of the largest enzyme families in the human ...

A team of researchers has established a new method to measure glomerular filtration rate (GFR), a primary kidney function, by calculating the clearance of D-serine. A team of researchers led by the ...

E. coli cells have now been engineered into producing large quantities of serine, which is used in detergents, tube feeding formula, and as building blocks for many important chemicals. Using the ...

In 2001, researchers noticed that serine—unlike other amino acids—formed a charged, eight-membered cluster during electrospray ionization mass spectrometry (Anal. Chem. 2001 DOI: 10.1021/ac010284l).

D-serine as an adjunctive treatment did not outperform placebo overall in patients with major depressive disorder (MDD), a new trial showed. However, depressive symptoms and anhedonia were ...

Of the 37 million patients in the U.S. with Type 2 diabetes, about half of them suffer from peripheral neuropathy, according to National Institutes of Health estimates. The condition causes numbness, ...

Serine serves as a metabolic nexus in tumors, coordinating one-carbon metabolism, nucleotide synthesis, and redox regulation. In recent years, targeting the serine metabolic pathway, particularly the ...

For optimal growth, tumors depend on the non-essential amino acids serine and glycine. Serine and glycine are biosynthetically linked and together, they provide the essential precursors for the ...

In findings that may shed light on the earliest days of evolutionary history, R. Graham Cooks and a team of Purdue chemists have reported experiments that suggest why all 20 of the amino acids that ...

Studies in mice by a Salk Institute research team have shown how altered amino acid metabolism can represent a contributing factor to diabetes-associated peripheral neuropathy. Their experiments found ...