Examples include inhibitors of cell cycle progression ... pRb inactivity most often involve frameshifts or deletions in the RB1 gene causing premature introduction of a stop codon and defective ...

“This work addresses a long-standing mystery surrounding an enzyme critical for regulating the cell cycle and cell proliferation,” said ... The protein, retinoblastoma protein 1 (RB1), is well known ...

could significantly suppress ESCC cell growth by targeting the CDK4/6-RB1 pathway, a key regulator of the cell cycle, thereby providing a promising therapeutic candidate for ESCC. The study ...