Examples include inhibitors of cell cycle progression ... pRb inactivity most often involve frameshifts or deletions in the RB1 gene causing premature introduction of a stop codon and defective ...
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Approved drug dronedarone found to inhibit the proliferation of esophageal squamous cell carcinomacould significantly suppress ESCC cell growth by targeting the CDK4/6-RB1 pathway, a key regulator of the cell cycle, thereby providing a promising therapeutic candidate for ESCC. The study ...
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