Necrotic cell death is a fundamental biological process, yet the terminal execution mechanisms of necrosis are still not ...

Cathepsins and cysteine proteases comprise a diverse family of enzymes that play central roles in intracellular protein degradation, cell signalling, and extracellular matrix remodelling. Their ...

Analysis of downstream pathways of important enzymatic biomolecules (e.g., kinases and proteases) that have multiple substrates has always been a difficult challenge. Targets of these enzymes could be ...

Detecting cancer in the earliest stages could dramatically reduce cancer deaths because cancers are usually easier to treat when caught early. To help achieve that goal, MIT and Microsoft researchers ...

Scientists have long struggled to target proteins that lack defined structure and are involved in cancer, neurodegenerative disorders like Parkinson's disease, and other serious illnesses. Now, a new ...

Pancreatic cancer is one of the most serious and deadly forms of cancer. It is often called a “silent” disease because it usually does not cause clear symptoms in its early stages. By the time it is ...

Researchers have shown how SARS-CoV-2 viral proteases attack the host cell, and how this can be targeted to stop virus replication in cell culture using existing drugs. The new findings offer a ...