More good news in the battle against opioid addiction. Scientists have reopened research into a class of opioids that were ...

Using a long-abandoned class of opioids as their starting point, scientists have discovered an opioid painkiller that doesn't have the side effects typical of this class of drugs (Nature 2026, DOI: 10 ...

An experimental opioid alternative called DFNZ achieved effective pain relief in mice without addiction risk or breathing ...

A novel mu-opioid receptor agonist showed strong analgesia without respiratory depression, tolerance, or significant ...

Narcotics can treat pain, but may also circumvent the need to address its cause. And, while pain may be diminished, the ...

Scientists have developed a new gene therapy that quiets pain at its source in the brain—without the addictive risks of opioids. Using AI to map how pain is processed, they created a targeted “off ...

Opioid drugs are highly effective at relieving pain but come with severe drawbacks. Their side effects range from dizziness to potentially fatal respiratory depression. Their illegal use contributes ...

An experimental drug developed at Duke University School of Medicine could offer powerful pain relief without the dangerous side effects of opioids. The drug, called SBI-810, is part of a new ...

Globally, opioid overdose deaths are more common than you think. It is one of the most important public health concerns, ...

Osteoarthritis affects around 600 million people globally. It causes pain, stiffness, and reduced joint function—most commonly in the knees, hands, and hips.

Naltrexone is a generic prescription drug used to treat certain substance use disorders. Naltrexone oral tablet does not come in any brand-name versions. This drug can cause mild to serious side ...